The progressive deposition of cholesterol along the wall of one or more of the three main arteries that supply the human heart muscle leads to the formation of fatty deposits called coronary atheroma. This can eventually lead to the restriction of blood flow causing individuals to experience chest pain when they exert themselves, for example whilst running or dealing with stressful situations.  This is known as Stable Angina.

There is increasing evidence to suggest that genes and proteins that are responsible for signalling damage to the genetic material inside human cells (called DNA) and pathways that undertake damage DNA, may be implicated in the molecular pathways that lead to the development of Coronary Atheroma.  We also have preliminary data that indicates that individuals with angina may have reduced DNA repair activity in their circulating blood cells, called perpheral blood mononuclear cells.

YOUR generous donations will enable our researchers to identify the molecular mechanism and the biological consequences of reduced DNA repair activity in individuals with stable angina.

We anticipate that our research will ultimately lead to the development of novel blood tests that can identify patients at risk of developing angina and further development of drugs that will reduce the development of coronary atheroma